There is nothing wrong with being open to an opportunity that enhances your career. This is a very critical question. Don't "bad mouth" your previous employer. If you are coming out of an organization known to have major problems, or in midst of a buy-out, down-sizing or re-engineering, this may be an easy question to answer. It is also good to state that after long personal consideration your chance to make a contribution is very low due to changes in the company. If you were not looking for a change when contacted by the recruiter to this interview, say so. There is nothing wrong with being open to an opportunity that advances your career.

Answers to this question can get you the job so prepare extensively. You may want to frame your answer into a two minute story, with details and discuss personal involvement. Describe how things were when you arrived, what you did to make the change and the measurable results. Discuss accomplishments that were worth achieving. Discuss hard work, long hours, pressure and any important issues at stake.

Be certain you know the specifics of the question - do they need a person to maintain the status quo or make major changes? Do they want staff development, a hands-on manager or an administrator to facilitate policies with upper administration?
Pick two or three main factors about the job and about you that are most relevant. Provide specific details. Select a clinical or technical skill or a specific management skill (organizing, staffing, planning), and combine it with a personal success attribute.

The interviewer is trying to determine your goal orientation, work ethic, personal commitment, and integrity. Provide a good example where you overcame numerous difficulties to succeed. Prove you're not a quitter, and that you'll "get going when the going gets tough."

The interviewer is trying to determine compatibility with the open position. If you have an interest in the position be careful. Stating that you dislike overtime or detail work can cost you the position. There is nothing wrong with liking challenges, pressure situations, opportunities to grow, or a dislike for bureaucracy or frustrating situations. Again, be positive about your current position

High achievers tend to perform well in high pressure situations. These questions also could imply that the position is pressure packed. If you do perform well under stress, provide an example with details, giving an overview of the stressful situation. Let the interviewer "feel" the stress by your description.